BDBM50618103 CHEMBL5436702::US12122771, Compound 1

SMILES C(CCc1nc2ccccc2s1)CN1CCN(CC1)c1ccccn1

InChI Key InChIKey=UTXSOICYDAGUJA-UHFFFAOYSA-N

Data  6 KI  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50618103   

TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataEC50:  1.24E+5nMAssay Description:Agonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataIC50: 123nMAssay Description:Antagonist activity at human D4 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataIC50: 849nMAssay Description:Antagonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataIC50: 104nMAssay Description:Antagonist activity at human D4 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataKi:  9.85nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent

TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataKi:  9.90nMAssay Description:Displacement of [3H]N-methylspiperone from human D4 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataKi:  58.5nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent

TargetD(3) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataKi:  59nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataKi:  408nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618103(CHEMBL5436702 | US12122771, Compound 1)
Affinity DataKi:  408nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent