BDBM50618106 CHEMBL5400876::US12122771, Compound 4

SMILES C(CN1CCN(CC1)c1ccccn1)Cc1nc2ccccc2s1

InChI Key InChIKey=KZVXSSLUUGFVFR-UHFFFAOYSA-N

Data  29 KI  7 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 43 hits for monomerid = 50618106   

Target5-hydroxytryptamine receptor 2B(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataIC50: 532nMAssay Description:Antagonist activity at 5-HT2B receptor (unknown origin) by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at 5-HT2B receptor (unknown origin) by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataEC50:  9.36E+5nMAssay Description:Agonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataIC50: 6.69E+3nMAssay Description:Antagonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human D4 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataIC50: 69nMAssay Description:Antagonist activity at human D4 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataEC50:  1.11E+3nMAssay Description:Agonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataEC50:  5.56E+3nMAssay Description:Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataIC50: 2.20E+4nMAssay Description:Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at human D4 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataEC50:  4.60E+3nMAssay Description:Agonist activity at 5-HT1A receptor (unknown origin) by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataIC50: 370nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]N-methylspiperone from human D4 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  2.21nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1A(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  5.80nMAssay Description:Binding affinity to 5-HT1A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  9.5nMAssay Description:Binding affinity to D4 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  13nMAssay Description:Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  46nMAssay Description:Binding affinity to 5-HT2A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  72nMAssay Description:Binding affinity to alpha2C adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  73nMAssay Description:Binding affinity to sigma 2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  107nMAssay Description:Binding affinity to 5-HT7 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  252nMAssay Description:Binding affinity to guinea pig sigma 1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAlpha-2A adrenergic receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  356nMAssay Description:Binding affinity to alpha2A adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  358nMAssay Description:Binding affinity to alpha2B adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAlpha-1B adrenergic receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  397nMAssay Description:Binding affinity to alpha1B adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistamine H1 receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  431nMAssay Description:Binding affinity to H1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  584nMAssay Description:Binding affinity to D3 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  586nMAssay Description:Binding affinity to alpha1A adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  634nMAssay Description:Binding affinity to NET (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  1.15E+3nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent

TargetD(3) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  1.15E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  1.27E+3nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  1.42E+3nMAssay Description:Binding affinity to 5-HT1D (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  2.27E+3nMAssay Description:Binding affinity to 5-HT5A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(1A) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  2.74E+3nMAssay Description:Binding affinity to D1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  2.76E+3nMAssay Description:Binding affinity to 5-HT1E (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  2.86E+3nMAssay Description:Binding affinity to 5-HT1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  2.93E+3nMAssay Description:In vitro binding affinities for various compounds within the scope of the present disclosure were determined using [3H]N-methylspiperone radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  2.93E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  3.55E+3nMAssay Description:Binding affinity to 5-HT2C (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAlpha-1D adrenergic receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50618106(CHEMBL5400876 | US12122771, Compound 4)
Affinity DataKi:  4.26E+3nMAssay Description:Binding affinity to alpha1D adrenergic receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed