BDBM50618164 CHEMBL5440131

SMILES COCC[C@H]1C[C@H]2CN3CCc4c([nH]c5ccc(OC)cc45)[C@](C(=O)OC)(C2)[C@H]13

InChI Key InChIKey=JLHTUHPOTUETFI-UHFFFAOYSA-N

Data  5 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50618164   

TargetMu-type opioid receptor(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618164BDBM50618164(CHEMBL5440131)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-DAGO from calf cortex MOR receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618164BDBM50618164(CHEMBL5440131)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]-U69593 from calf cortex KOR receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Bos taurus)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618164BDBM50618164(CHEMBL5440131)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-DTG from calf hippocampus sigma 2 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMuscarinic receptor M1(Bovine)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618164BDBM50618164(CHEMBL5440131)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-pirenzepine from calf cortex Muscarinic M1 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618164BDBM50618164(CHEMBL5440131)
Affinity DataKi:  400nMAssay Description:Displacement of [3H]imipramine from human alpha3beta4 nAChRs expressed in HEK293 cells assessed as inhibition constant incubated for 2 hrs by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618164BDBM50618164(CHEMBL5440131)
Affinity DataIC50: 750nMAssay Description:Antagonist activity at recombinant alpha3beta4 nAChR in HEK293 cells by voltage-clamp based electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618164BDBM50618164(CHEMBL5440131)
Affinity DataIC50: 1.47E+3nMAssay Description:Antagonist activity at human alpha3beta4 nAChRs expressed in HEK293 cells assessed as inhibition of (+/-)-epibatidine-induced Ca+2 influx incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618164BDBM50618164(CHEMBL5440131)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of nAChR alpha4beta2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618164BDBM50618164(CHEMBL5440131)
Affinity DataIC50: 2.00E+4nMAssay Description:Antagonist activity at alpha4beta2 nAChR in HEK293 cells by voltage-clamp based electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618164BDBM50618164(CHEMBL5440131)
Affinity DataIC50: 3.47E+4nMAssay Description:Inhibition of nAChR alpha7 receptor (unknown origin) assessed as inhibition of calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed