BDBM50620358 CHEMBL5434489

SMILES Cc1cc(sn1)Nc2ncc(c(n2)N3CC(C3)(C4CC4)O)C

InChI Key InChIKey=AYYRUOOCJNTWHJ-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50620358   

TargetTyrosine-protein kinase JAK2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620358(CHEMBL5434489)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSignal transducer and activator of transcription 3(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620358(CHEMBL5434489)
Affinity DataIC50: 83nMAssay Description:Inhibition of IL-6 stimulated STAT3 phosphorylation in HEK-Blue IL-6 cells incubated for 20 to 24 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620358(CHEMBL5434489)
Affinity DataIC50: 0.970nMAssay Description:Inhibition of AURKB (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620358(CHEMBL5434489)
Affinity DataIC50: 31nMAssay Description:Inhibition of KDR (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620358(CHEMBL5434489)
Affinity DataIC50: 80nMAssay Description:Inhibition of ABL1 (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50620358(CHEMBL5434489)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of GSK3B (unknown origin) incubated for 45 to 120 mins in presence of ATP by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed