BDBM50622128 CHEMBL5424861

SMILES [H][C@]12CC3C[C@]([H])(CC(O)(C3)C1)C2Nc1c(cnc2[nH]ccc12)C(N)=O

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50622128   

TargetTyrosine-protein kinase JAK1(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50622128(CHEMBL5424861)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of N-terminal GST tagged catalytic domain human JAK1 (850 to 1154 end residues) expressed in Sf21 insect cells using Biotin-Lyn-Substrate-...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50622128(CHEMBL5424861)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal His-tagged catalytic domain human JAK2 (826 to 1132 end residues) expressed in Sf21 insect cells using Biotin-Lyn-Substrate-...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50622128(CHEMBL5424861)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal His-tagged catalytic domain human JAK3 (795 to 1124 residues) expressed in Sf21 insect cells using Biotin-Lyn-Substrate-2 as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50622128(CHEMBL5424861)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of N-terminal GST tagged catalytic domain human TYK2 (871 to 1187 end residues) expressed in Sf21 insect cells using Biotin-IRS1-Substrate...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed