BDBM50622218 CHEMBL5395449::US20250353857, Compound TIA04-139

SMILES CN(Cc1cc(C)ccc1O)c1ncnc2[nH]c(cc12)-c1ccc(CO)cc1

InChI Key InChIKey=OEBROKXGEWKVMU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50622218   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Norwegian University of Science and Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50622218BDBM50622218(CHEMBL5395449 | US20250353857, Compound TIA04-139)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CSF1R (530 to 910 residues) (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Norwegian University of Science and Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50622218BDBM50622218(CHEMBL5395449 | US20250353857, Compound TIA04-139)
Affinity DataIC50: 1.70nMAssay Description:The compounds were supplied in a 10 mM DMSO solution, and enzymatic CSF1R inhibition potency was determined by Invitrogen (TermoFisher) using their Z...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Norwegian University of Science and Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50622218BDBM50622218(CHEMBL5395449 | US20250353857, Compound TIA04-139)
Affinity DataIC50: 500nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed