BDBM50622269 CHEMBL5437508

SMILES C[C@H]1CN(CCN1c1ccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)nc1)C(=O)CCCCCCCCCCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

InChI Key InChIKey=HYZMVIWTOQSXRR-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50622269   

TargetTyrosine-protein kinase BTK(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50622269(CHEMBL5437508)
Affinity DataKd:  107nMAssay Description:Binding affinity to full length BTK (unknown origin) assessed as dissociation constant measured at 37 degree C by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50622269(CHEMBL5437508)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of BTK in HEK293 cells using NanoGlo substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50622269(CHEMBL5437508)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CRBN in HEK293 cells using NanoGlo substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed