BDBM50623117 CHEMBL5421204

SMILES C[C@H]1CC(C(=O)CC#N)[C@]11CCN(C1)c1ncnc2[nH]ccc12

InChI Key InChIKey=MWKQYEXUIAHUAU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50623117   

TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50623117(CHEMBL5421204)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human JAK2 (808 to end residues) using biotinylated TK substrate in presence of [33P]ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50623117(CHEMBL5421204)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant human JAK1 (850 to end residues) using biotinylated TK substrate in presence of [33P]ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50623117(CHEMBL5421204)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human JAK3 (781 to end residues) using biotinylated TK substrate in presence of [33P]ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50623117(CHEMBL5421204)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant human TYK2 (871 to end residues) using biotinylated TK substrate in presence of [33P]ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed