BDBM50627705 CHEMBL5408922::US20250017936, Compound II559
SMILES CC(=O)N(CC#Cc1ccc(Cl)c(c1)C(N)=O)C[C@H]1C[C@H]([C@H](O)[C@@H]1O)n1ccc2c(Cl)ncnc12
InChI Key InChIKey=OJTMOLQULTUMAM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50627705
Affinity DataIC50: 140nMAssay Description:Inhibition of NNMT in human 769-P cells assessed as reduction in MNA level measured after 48 hrs by MRM analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of full-length recombinant human NNMT expressed in Escherichia coli BL21(DE3) cells using nicotinamide as substrate preincubated for 30 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of full-length recombinant human NNMT expressed in Escherichia coli BL21(DE3) cells using nicotinamide as substrate preincubated for 30 mi...More data for this Ligand-Target Pair
Affinity DataKd: 147nMAssay Description:Binding affinity to full-length wild-type human NNMT (1 to 270 residues) expressed in Escherichia coli BL21(DE3) cells assessed as dissociation const...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of NNMT in human 769-P cells assessed as MNA level incubated for 24 hrs by MRM analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of NNMT in human 769-P cells assessed as MNA level incubated for 48 hrs by MRM analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description: As the sensitivity of the FAP assay is limited by the binding affinity of the probe for NNMT, the inhibitory concentration was further determined us...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description: As the sensitivity of the FAP assay is limited by the binding affinity of the probe for NNMT, the inhibitory concentration was further determined us...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity to full-length wild-type human NNMT (1 to 270 residues) expressed in Escherichia coli BL21(DE3) cells assessed as apparent inhibitio...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity to full-length recombinant human NNMT expressed in Escherichia coli BL21(DE3) cells assessed as apparent inhibition constant using n...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of full-length recombinant human NNMT expressed in Escherichia coli BL21(DE3) cells using nicotinamide as substrate preincubated for 30 mi...More data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Binding affinity to full-length recombinant human NNMT expressed in Escherichia coli BL21(DE3) cells assessed as inhibition constant preincubated for...More data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:The inhibitory constants (Ki) of the synthesized inhibitors were first determined using a fluorescence polarization (FP)-based competition assay with...More data for this Ligand-Target Pair
Affinity DataKi: 1.52E+4nMAssay Description:The inhibitory constants (Ki) of the synthesized inhibitors were first determined using a fluorescence polarization (FP)-based competition assay with...More data for this Ligand-Target Pair