BDBM50627868 CHEMBL5440296

SMILES c1cc(ccc1Nc2nc(nc(n2)Oc3ccc4c(c3)cc[nH]4)N)S(=O)(=O)N

InChI Key InChIKey=NLUNRZKTOSCDJH-UHFFFAOYSA-N

Data  4 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50627868   

TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627868(CHEMBL5440296)
Affinity DataKd:  8.00E+3nMAssay Description:Binding affinity to JAK2 V617F mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627868(CHEMBL5440296)
Affinity DataKd:  4.11E+4nMAssay Description:Binding affinity to JAK2 JH1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627868(CHEMBL5440296)
Affinity DataKd:  1.83E+4nMAssay Description:Binding affinity to wild type JAK2 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627868(CHEMBL5440296)
Affinity DataKd:  1.60E+4nMAssay Description:Binding affinity to JAK2 JH1 (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)