BDBM50627869 CHEMBL5416600::US20250034112, Compound 33n

SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nc(Oc2ccc3[nH]c(COCC(O)=O)cc3c2)n1

InChI Key InChIKey=NJWNFBXPGNZJDQ-UHFFFAOYSA-N

Data  8 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50627869   

TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627869(CHEMBL5416600 | US20250034112, Compound 33n)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to JAK2 V617F mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627869(CHEMBL5416600 | US20250034112, Compound 33n)
Affinity DataKd:  2.60E+3nMAssay Description:Binding affinity to wild type JAK2 JH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627869(CHEMBL5416600 | US20250034112, Compound 33n)
Affinity DataKd:  2.60E+3nMAssay Description:Binding affinity to wild type JAK2 JH2 (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627869(CHEMBL5416600 | US20250034112, Compound 33n)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to JAK2 JH2 V617F mutant (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50627869(CHEMBL5416600 | US20250034112, Compound 33n)
Affinity DataKd:  4.11E+4nMAssay Description:Binding affinity JAK2 JH1 (unknown origin) assessed as dissociation constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Yale University

US Patent
LigandPNGBDBM50627869(CHEMBL5416600 | US20250034112, Compound 33n)
Affinity DataKd:  4.11E+4nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [536-812](Human)
Yale University

US Patent
LigandPNGBDBM50627869(CHEMBL5416600 | US20250034112, Compound 33n)
Affinity DataKd:  2.60E+3nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [536-812,V617F](Human)
Yale University

US Patent
LigandPNGBDBM50627869(CHEMBL5416600 | US20250034112, Compound 33n)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinities (Kd) with the JAK2 JH2 domain were evaluated using the previously developed FP assay and compound 1 as a control. An initial scree...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent