BDBM50628241 CHEMBL5408585

SMILES COC(=O)c1cc(O)c2cc(NC(=O)NCCNC(=N)NC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)ccc2c1

InChI Key InChIKey=FOKMEBMJOQIKNH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50628241   

TargetProtein arginine N-methyltransferase 9(Homo sapiens)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628241(CHEMBL5408585)
Affinity DataIC50: 2.47E+3nMAssay Description:Inhibition of human recombinant PRMT9 using biotinylated SF3B2(500 to 519 residues) as substrate and SAM as cosubstrate pre-incubated with compound f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628241(CHEMBL5408585)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal/C-terminal GST-tagged human recombinant full-length PRMT1 (2 to 371 residues) using histone H4 as substrate and 3H-SAM as co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628241(CHEMBL5408585)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal/C-terminal His-tagged human recombinant full-length PRMT3 (2 to 531 residues) using histone H4 as substrate and 3H-SAM as co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628241(CHEMBL5408585)
Affinity DataIC50: 2.28E+4nMAssay Description:Inhibition of N-terminal/C-terminal GST-tagged human recombinant full-length PRMT4 (2 to 608 residues) using histone H3.3 as substrate and 3H-SAM as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628241(CHEMBL5408585)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of N-terminal/C-terminal human recombinant full-length FLAG-tagged PRMT5 (2 to 637 residues)/C-terminal human His-tagged MEP50 (2 to 342 r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628241(CHEMBL5408585)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of N-terminal/C-terminal GST-tagged human recombinant full-length PRMT6 (2 to 375 residues) using histone GST-GAR as substrate and 3H-SAM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628241(CHEMBL5408585)
Affinity DataIC50: 540nMAssay Description:Inhibition of N-terminal/C-terminal His-tagged human recombinant full-length PRMT7 (2 to 692 residues) using histone GST-GAR as substrate and 3H-SAM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50628241(CHEMBL5408585)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of N-terminal/C-terminal His-tagged human recombinant full-length PRMT8 (61 to 394 residues) using histone H4 as substrate and 3H-SAM as c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed