BDBM50628726 CHEMBL5408929

SMILES Cc1cn(cn1)-c1cc(NC(=O)c2cc3OCCCCCCNC(=O)c4ccc5ncc(C#Cc(c3)c2C)n5n4)cc(c1)C(F)(F)F

InChI Key InChIKey=LNSSOTMJRRLINS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50628726   

TargetNT-3 growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628726(CHEMBL5408929)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of TRKC (unknown origin) using Ser/Thr 06 as peptide substrate incubated for 1 hr in presence of ATP by FRET based Z-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628726(CHEMBL5408929)
Affinity DataIC50: 12nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) expressed in baculovirus expression system Sf9 cells using Ser/Thr 06 as peptide substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628726(CHEMBL5408929)
Affinity DataIC50: 52nMAssay Description:Inhibition of N-terminal hexa his tagged TRKA (485 to 795 residues) (unknown origin) expressed in baculovirus expression system Sf9 cells using Ser/T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50628726(CHEMBL5408929)
Affinity DataIC50: 562nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) expressed in baculovirus expression system Sf9 cells using Ser/Thr 06 as peptide substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed