BDBM50629112 CHEMBL5408043

SMILES COc1cccc2n(c(nc12)C(F)F)-c1nc(cc(n1)N1CCN(CC1)C(=S)SCC(=O)N1CCOCC1)N1CCOCC1

InChI Key InChIKey=BRNCLSYLICSNRO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50629112   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50629112(CHEMBL5408043)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal GST-fused full-length human PI3Kalpha (1 to 1068 residues) expressed in baculovirus expression system using PIP2 as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50629112(CHEMBL5408043)
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal 6xHis-tagged recombinant, full length human PI3Kbeta by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50629112(CHEMBL5408043)
Affinity DataIC50: 35nMAssay Description:Inhibition of human PI3Kgamma expressed in baculovirus infected Sf21 insect cells by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50629112(CHEMBL5408043)
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal 6xHis-tagged recombinant full-length human PI3Kdelta expressed in baculovirus infected Sf21 insect cells by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed