BDBM50630223 CHEMBL5396134

SMILES CN(C)S(=O)(=O)c1cccc(c1)-c1c[nH]c2cnc(NC(C)=O)cc12

InChI Key InChIKey=DTMIBBOCLJONAM-UHFFFAOYSA-N

Data  3 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50630223   

LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TYK2 JH2 domain (577 to 870 residues) expressed in Sf9 cells using N-(2-(2-(2-((3-(5-acetamido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataEC50:  120nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataEC50:  1.97E+4nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataEC50: >1.90E+4nMAssay Description:Inhibition of JAK2 in human UT7 cells assessed as reduction in erythropoietin induced STAT5 phosphorylation preincubated for 30 mins followed by eryt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataEC50: >1.90E+4nMAssay Description:Inhibition of JAK3 in human T-blast cells assessed as reduction in IL-2 induced STAT5 phosphorylation preincubated for 30 mins followed by IL-2 stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed