BDBM50630225 CHEMBL5414765

SMILES CN(C)S(=O)(=O)c1cccc(c1)-c1cn(C)c2cnc(NC(C)=O)cc12

InChI Key InChIKey=ZLPIVHFIHIBJHH-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50630225   

LigandPNGBDBM50630225(CHEMBL5414765)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TYK2 JH2 domain (577 to 870 residues) expressed in Sf9 cells using N-(2-(2-(2-((3-(5-acetamido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630225(CHEMBL5414765)
Affinity DataEC50:  20nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630225(CHEMBL5414765)
Affinity DataEC50:  6.80E+3nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed