BDBM50630348 CHEMBL5419067

SMILES Nc1ccc2c(OCCOCCOc3cccc4nc(N)ccc34)cccc2n1

InChI Key InChIKey=WAAWFZAMZGNKQF-UHFFFAOYSA-N

Data  5 KI  3 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50630348   

TargetNeutrophil cytosol factor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataKd:  710nMAssay Description:Binding affinity to His-tagged human p47phox (151 to 386 residues) expressed in Escherichia coli BL21 (DE3) pLysS assessed as dissociation constant a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNeutrophil cytosol factor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataKd:  790nMAssay Description:Binding affinity to His-tagged human p47phox (151 to 386 residues) expressed in Escherichia coli BL21 (DE3) pLysS assessed as kinetics dissociation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNeutrophil cytosol factor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to His-tagged human p47phox (151 to 386 residues) expressed in Escherichia coli BL21 (DE3) pLysS assessed as dissociation constant b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of NOX-2 dependent superoxide generation in PMA-differentiated human PLB-985 cells incubated for 1 hr by WST-1 based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of NOX2 (unknown origin) transfected in COS cells assessed as reduction in PMA-stimulated H2O2 production preincubated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of NOX5 (unknown origin) transfected in HEK cells assessed as reduction in PMA/ionomycin-stimulated H2O2 production preincubated for 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNeutrophil cytosol factor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataKi:  240nMAssay Description:Inhibition of Cy5-labeled p22phox (149 to 162 residues) probe binding to His-tag cleaved human p47phox (151 to 386 residues) expressed in Escherichia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNeutrophil cytosol factor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataKi:  600nMAssay Description:Inhibition of Cy5-labeled p22phox (149 to 162 residues) probe binding to His-tagged human p47phox (151 to 286 residues) expressed in Escherichia coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNeutrophil cytosol factor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of Cy5-labeled p22phox (149 to 168 residues) probe binding to His-tagged human p47phox (151 to 386 residues) expressed in Escherichia coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNeutrophil cytosol factor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of Cy5-labeled p22phox (149 to 168 residues) probe binding to His-tag cleaved human p47phox (151 to 386 residues) expressed in Escherichia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNeutrophil cytosol factor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of Cy5-labeled p22phox (149 to 168 residues) probe binding to His-tag cleaved human p47phox (151 to 386 residues) expressed in Escherichia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed