BDBM50630412 CHEMBL5402198

SMILES CC(C)C[C@H](NC(=O)CNC(=O)CC[C@H](NS(=O)(=O)c1ccc(Cl)c(c1)C(F)(F)F)C(O)=O)C(=O)N[C@H](C(=O)N1CCC[C@H]1CC(N)=O)C(C)(C)C

InChI Key InChIKey=WVSIAOYHEIZRMM-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50630412   

TargetMatrilysin(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630412(CHEMBL5402198)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of recombinant human MMP7 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-14(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630412(CHEMBL5402198)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant human MMP14 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630412(CHEMBL5402198)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of recombinant human MMP12 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630412(CHEMBL5402198)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of recombinant human MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNeutrophil collagenase(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630412(CHEMBL5402198)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of recombinant human MMP8 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630412(CHEMBL5402198)
Affinity DataIC50: 9.20E+4nMAssay Description:Inhibition of recombinant human MMP1 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetStromelysin-1(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630412(CHEMBL5402198)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP3 using MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630412(CHEMBL5402198)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP9 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetCollagenase 3(Human)
Taisho Pharmaceutical Co.

Curated by ChEMBL
LigandPNGBDBM50630412(CHEMBL5402198)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP13 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed