BDBM50631288 CHEMBL5398372

SMILES CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(cc2)C(F)(F)F)[C@H](C)C1

InChI Key InChIKey=LLXUFTFQOVBHRV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50631288   

TargetTyrosine-protein kinase JAK2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631288(CHEMBL5398372)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631288(CHEMBL5398372)
Affinity DataIC50: 866nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631288(CHEMBL5398372)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631288(CHEMBL5398372)
Affinity DataIC50: 957nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631288(CHEMBL5398372)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant TYK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631288(CHEMBL5398372)
Affinity DataIC50: 789nMAssay Description:Inhibition of recombinant TYK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631288(CHEMBL5398372)
Affinity DataIC50: 0.563nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631288(CHEMBL5398372)
Affinity DataIC50: 112nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed