BDBM50631824 CHEMBL5401267

SMILES CS(=O)(=O)N1CCc2cc(Nc3ncc(c(NCCCN)n3)C(F)(F)F)ccc2C1

InChI Key InChIKey=PROGKLMIRQVLRO-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50631824   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 23nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate reader ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 26nMAssay Description:Inhibition of CHK1 (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 16nMAssay Description:Inhibition of wildtype FLT3 (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate reader analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of c-kit (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 865nMAssay Description:Inhibition of IRAK4 (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 835nMAssay Description:Inhibition of p70S6K (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 834nMAssay Description:Inhibition of CDK2 (unknown origin) incubated for 1 hrs by fluorescence microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetAurora kinase A(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of Aurora A (unknown origin) expressed in Escherichia coli using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIM1 (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase 17B(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50631824(CHEMBL5401267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DRAK2 (unknown origin) expressed in Escherichia coli incubated for 2 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed