BDBM50632918 CHEMBL5396725

SMILES Cc1nnc(-c2ccc3[nH]nc(C)c3c2)n1Cc1ccc(cc1)C(F)(F)F

InChI Key InChIKey=IXRCZLGBPPMVSP-UHFFFAOYSA-N

Data  2 IC50  8 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50632918   

TargetCyclin-C(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of His tagged human recombinant CDK8/Cyclin C expressed in baculovirus expression system incubated for 15 mins by FRET-based LanthaScreen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataKd:  89nMAssay Description:Binding affinity to CLK1 (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataKd:  68nMAssay Description:Binding affinity to CLK2 (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCasein kinase I isoform gamma-3(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataKd:  860nMAssay Description:Binding affinity to CSNK1G3 (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to DYRK1B (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataKd:  240nMAssay Description:Binding affinity to GSK3A (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataKd:  210nMAssay Description:Binding affinity to GSK3B (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase LATS2(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataKd:  250nMAssay Description:Binding affinity to LATS2 (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataKd:  4.20E+3nMAssay Description:Binding affinity to VPS34 (unknown origin) assessed as dissociation constant by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 19(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50632918(CHEMBL5396725)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed