BDBM50632920 CHEMBL5404639

SMILES CN1CCN(CC1)c2ccc(cc2)Nc3nc4ccc(cc4c(n3)Nc5cccc(c5)NC(=O)C=C)F

InChI Key InChIKey=KDWNVZXLHSMELQ-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50632920   

TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632920(CHEMBL5404639)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human partial length EGFR (R669 to V1011 residues) L858R/T790M mutant expressed in mammalian expression system by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632920(CHEMBL5404639)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human partial length EGFR (R669 to V1011 residues) L858R mutant expressed in bacterial expression system by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632920(CHEMBL5404639)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human partial length EGFR (R669 to G1022 residues) T790M mutant expressed in mammalian expression system by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632920(CHEMBL5404639)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human EGFR exon del19 mutant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Tec(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632920(CHEMBL5404639)
Affinity DataIC50: 518nMAssay Description:Inhibition of human wild type partial length TEC kinase (L341 to D620 residues) expressed in bacterial expression system by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632920(CHEMBL5404639)
Affinity DataIC50: 603nMAssay Description:Inhibition of human wild type partial length Src kinase (L240 to L536 residues) expressed in bacterial expression system by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSTE20-like serine/threonine-protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632920(CHEMBL5404639)
Affinity DataIC50: 892nMAssay Description:Inhibition of human wild type partial length SLK (S14 to A307 residues) expressed in bacterial expression system by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632920(CHEMBL5404639)
Affinity DataIC50: 3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632920(CHEMBL5404639)
Affinity DataIC50: 1.29E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)