BDBM506344 US11045448, Cpd. No. 12::methyl ((1S,2R)-2-((S)-(1-((1-(4-((3- acrylamidophenyl)sulfonyl)phenyl)-3-fluoroazetidin-3- yl)methyl)piperidin-4-yl)(cyano)(3- fluorophenyl)methyl)cyclopentyl)carbamate

SMILES COC(=O)N[C@H]1CCC[C@@H]1[C@@](C#N)(C1CCN(CC2(F)CN(C2)c2ccc(cc2)S(=O)(=O)c2cccc(NC(=O)C=C)c2)CC1)c1cccc(F)c1

InChI Key InChIKey=LQMSDXRSIFSIKF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 506344   

TargetMenin(Human)
University of Michigan

US Patent
LigandPNGBDBM506344(methyl ((1S,2R)-2-((S)-(1-((1-(4-((3- acrylamidoph...)
Affinity DataIC50: 42nMAssay Description:A fluorescence polarization (FP) competitive binding assay was used to determine the binding affinities of representative menin inhibitors. A FAM lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent