BDBM50634627 NLRP3 Compound 1

SMILES [2H]C1([2H])CCc3c1cc2CCCc2c3NC(=O)NS(=O)(=O)c4cc(C(C)(C)O)co4

InChI Key InChIKey=HUUSXLKCTQDPGL-BFWBPSQCSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50634627   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50634627(NLRP3 Compound 1)
Affinity DataIC50: 6nMAssay Description:Inhibition of NLRP3 in human monocyte derived macrophages assessed as reduction in LPS-induced IL-1beta production incubated for 30 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed