BDBM50635683 CHEMBL5559059

SMILES COCOc1ccc(-c2cn(C)c3cc(NC(=O)c4ccc(C)c(C#Cc5ccnc6[nH]ncc56)c4)ccc23)cc1

InChI Key InChIKey=JOSUWBQNUKVUJH-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50635683   

TargetInactive tyrosine-protein kinase transmembrane receptor ROR1(Homo sapiens)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635683BDBM50635683(CHEMBL5559059)
Affinity DataKd:  100nMAssay Description:Binding affinity to N-terminal poly his tagged recombinant human ROR1 (Met453 to Asn783 residues) extracted from Baculovirus infected in Insect cell ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetInactive tyrosine-protein kinase transmembrane receptor ROR1(Homo sapiens)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635683BDBM50635683(CHEMBL5559059)
Affinity DataKd:  100nMAssay Description:Binding affinity to ROR1 kinase domain (453 to 783 residues) (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetInactive tyrosine-protein kinase transmembrane receptor ROR1(Homo sapiens)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635683BDBM50635683(CHEMBL5559059)
Affinity DataIC50: 325nMAssay Description:Inhibition of N-terminal GST tagged human wild type ROR1 (452 to 753 residues) extracted from Escherichia coli using biotinylated TK-peptide as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetInactive tyrosine-protein kinase transmembrane receptor ROR1(Homo sapiens)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635683BDBM50635683(CHEMBL5559059)
Affinity DataIC50: 630nMAssay Description:Inhibition of ROR1 (unknown origin) kinase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed