BDBM50643277 CHEMBL5569561

SMILES O=C(NO)c1cccc(-n2cc(CSc3ccccc3)nn2)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50643277   

TargetHistone deacetylase 8(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50643277(CHEMBL5569561)
Affinity DataIC50: 53nMAssay Description:Inhibition of HDAC8 (unknown origin) assessed as release of fluorogenic AMC pre-incubated for 15 mins followed by addition of trypsin and substrate m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50643277(CHEMBL5569561)
Affinity DataIC50: 53nMAssay Description:Inhibition of human recombinant HDAC8 using fluorogenic HDAC substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50643277(CHEMBL5569561)
Affinity DataIC50: 53nMAssay Description:Inhibition of HDAC8 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate measured after 30 mins by fluorescence a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50643277(CHEMBL5569561)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC1 (unknown origin) using Ac-Leu-Gly-Lys(Ac)-AMC as substrate pre-incubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50643277(CHEMBL5569561)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC4 (unknown origin) assessed as release of fluorogenic AMC pre-incubated for 15 mins followed by addition of trypsin and substrate m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50643277(CHEMBL5569561)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC2 (unknown origin) assessed as release of fluorogenic AMC pre-incubated for 15 mins followed by addition of trypsin and substrate m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed