BDBM50651192 CHEMBL5633837

SMILES COc1cc(-c2n[nH]c3ncc(-c4ccc(C)c(NCCO)c4)cc23)cc(OC)c1OC

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50651192   

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to human BMPR1B assessed as dissociation constant by Adp-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to human JNK3 assessed as dissociation constant by Adp-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  6.70nMAssay Description:Binding affinity to human MEK5 assessed as dissociation constant by Adp-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase 16(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  11nMAssay Description:Binding affinity to human STK16 assessed as dissociation constant by Adp-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataIC50: 12nMAssay Description:Inhibition of human FLT3 using MBP as substrate in presence of ATP by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  14nMAssay Description:Binding affinity to human ABL1 assessed as dissociation constant by Adp-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  14nMAssay Description:Binding affinity to human JNK2 assessed as dissociation constant by Adp-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  26nMAssay Description:Binding affinity to human FLT3 assessed as dissociation constant by Adp-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMyotonin-protein kinase(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  30nMAssay Description:Binding affinity to human DMPK assessed as dissociation constant by Adp-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  33nMAssay Description:Binding affinity to human FLT3 ITD/D835V double mutant assessed as dissociation constant by Adp-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  34nMAssay Description:Binding affinity to human FLT3 ITD mutant assessed as dissociation constant by Adp-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  36nMAssay Description:Binding affinity to human JNK1 assessed as dissociation constant by Adp-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataIC50: 88nMAssay Description:Inhibition of human ABL1 in presence of ATP by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed