BDBM50652761 CHEMBL5639259::US20250268877, Example 76

SMILES CC(C)Oc1nc2nn(C34COC(C)(C3)C4)cc2cc1C(=O)Nc1cccn([C@H]2C[C@H]2C)c1=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50652761   

LigandPNGBDBM50652761(CHEMBL5639259 | US20250268877, Example 76)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of IRAK4 (unknown origin) incubated for 1 hr in presence of ATP by Mesoscale assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652761(CHEMBL5639259 | US20250268877, Example 76)
Affinity DataIC50: 200nMAssay Description:IRAK4 protein. N-terminal His-TEV-AVI tagged catalytical domain of human IRAK4 (a.a. 163-460) was co-expressed with Bir A in insect cells, and purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

LigandPNGBDBM50652761(CHEMBL5639259 | US20250268877, Example 76)
Affinity DataIC50: 743nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-1beta production preincubated with compound for 1 hr followed by R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed