BDBM50659234 CHEMBL4527793

SMILES [H]/N=C\1/NC(=O)/C(=C\c2ccc(cc2)N)/S1

InChI Key InChIKey=QXOIZYPBCJHYLN-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50659234   

TargetDouble-strand break repair protein MRE11(Human)
Masaryk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659234BDBM50659234(CHEMBL4527793)
Affinity DataIC50: 1.17E+5nMAssay Description:Inhibition of human MRE11 expressed in insect High Five cells using fluorescent-labeled 5'-overhang DNA as substrate preincubated for 20 mins followe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetFlap endonuclease 1(Human)
Masaryk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659234BDBM50659234(CHEMBL4527793)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human FEN1 expressed in Escherichia coli cells using 5'-Flap DNA as substrate preincubated for 20 mins followed by substrate addition a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetExonuclease 1(Human)
Masaryk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659234BDBM50659234(CHEMBL4527793)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human EXO1 expressed in Escherichia coli BL21 (RIPL) cells using 3'-overhang DNA as substrate preincubated for 20 mins followed by subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetDouble-strand break repair protein MRE11(Human)
Masaryk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659234BDBM50659234(CHEMBL4527793)
Affinity DataIC50: 3.17E+5nMAssay Description:Inhibition of human MRE11 expressed in insect High Five cells using fluorescent-labeled 5'-overhang DNA as substrate preincubated for 20 mins followe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed