BDBM50660042 CHEMBL6146508

SMILES C[C@@H](c1ccncc1)N(C)C(=O)N[C@@H]1COCC1(F)F

InChI Key InChIKey=BDCYNMOBTJPEHV-UHFFFAOYSA-N

Data  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50660042   

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660042BDBM50660042(CHEMBL6146508)
Affinity DataKd: <33nMAssay Description:Binding affinity to human SARM1 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Rattus norvegicus)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660042BDBM50660042(CHEMBL6146508)
Affinity DataIC50: 253nMAssay Description:Inhibition of rat SARM1 extracted from HEK293 cell lysate in presence of NAD by biochemical (Fluorescence Readout) assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660042BDBM50660042(CHEMBL6146508)
Affinity DataIC50: 285nMAssay Description:Inhibition of human SARM1 expressed in human SH-SY5Y cells assessed as SARM1 P1a activity measured after 60 mins by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660042BDBM50660042(CHEMBL6146508)
Affinity DataIC50: 300nMAssay Description:Inhibition of human SARM1 extracted from HEK293 cell lysate in presence of NAD by biochemical (Fluorescence Readout) assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Mus musculus)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660042BDBM50660042(CHEMBL6146508)
Affinity DataIC50: 318nMAssay Description:Inhibition of mouse SARM1 extracted from HEK293 cell lysate in presence of NAD by biochemical (Fluorescence Readout) assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNicotinamide/nicotinic acid mononucleotide adenylyltransferase 1(Homo sapiens)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660042BDBM50660042(CHEMBL6146508)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NMNAT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2(Homo sapiens)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660042BDBM50660042(CHEMBL6146508)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CD157 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660042BDBM50660042(CHEMBL6146508)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CD38 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed