BDBM50660053 CHEMBL6143553

SMILES C[C@@H](c1ccnnc1)N(C)C(=O)N[C@@H]1COCC1(F)F

InChI Key InChIKey=LREWZIFCQFUBBA-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50660053   

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660053BDBM50660053(CHEMBL6143553)
Affinity DataKd:  12nMAssay Description:Binding affinity to human SARM1 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660053BDBM50660053(CHEMBL6143553)
Affinity DataIC50: 689nMAssay Description:Inhibition of human SARM1 extracted from HEK293 cell lysate in presence of NAD by biochemical (Fluorescence Readout) assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660053BDBM50660053(CHEMBL6143553)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of human SARM1 expressed in human SH-SY5Y cells assessed as SARM1 P1a activity measured after 60 mins by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed