BDBM50660663 CHEMBL6172244

SMILES CC#CCn1cc(N(CC2CC2)c2nc(C(N)=O)c(-c3cc(C(=O)N(C)C)c[nH]3)s2)cn1

InChI Key InChIKey=HACYEVIDLDLIII-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50660663   

TargetTGF-beta receptor type-1(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of ALK5 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetActivin receptor type-1C(Homo sapiens)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of ALK7 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 21nMAssay Description:Inhibition of ALK1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMothers against decapentaplegic homolog 3(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 22nMAssay Description:Inhibition of TGFbeta-stimulated SMAD3 phosphorylation in human A549 cells preincubated for 1 hrs followed by human TGF-beta1 addition and measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetActivin receptor type-1B(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 35nMAssay Description:Inhibition of ALK4 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 65nMAssay Description:Inhibition of ALK2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 76nMAssay Description:Inhibition of TrkC (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetAurora kinase C(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 114nMAssay Description:Inhibition of Aurora Kinase C (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 269nMAssay Description:Inhibition of ALK3 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetActivin receptor type-2B(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 364nMAssay Description:Inhibition of ACTR2B (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetActivin receptor type-2A(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 671nMAssay Description:Inhibition of ACVR2A (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 999nMAssay Description:Inhibition of ALK6 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-2(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660663BDBM50660663(CHEMBL6172244)
Affinity DataIC50: 3.26E+3nMAssay Description:Inhibition of BMPR2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed