BDBM50660682 CHEMBL6162015

SMILES COc1nc(-c2cc(-c3cnn(C)c3)cnc2N)cc2c1C(=O)N(CC(F)(F)F)CC2

InChI Key InChIKey=CHHWWKMJOARNHH-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50660682   

TargetSerine/threonine-protein kinase SIK2(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant full length human SIK2 assessed as luminescence signal using AMARAtide/ATP as substrate measured after 120 mins by micropla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human SIK3 assessed as luminescence signal using AMARAtide/ATP as substrate measured after 120 mins by microplate readerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 15nMAssay Description:Binding affinity to human MKNK2 by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 31nMAssay Description:Binding affinity to human PDGFRalpha by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 35nMAssay Description:Inhibition of human SIK1 (02 to 131) assessed as luminescence signal using AMARAtide/ATP as substrate measured after 120 mins by microplate readerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 85nMAssay Description:Binding affinity to human FLT3 by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 230nMAssay Description:Binding affinity to human TBK1 by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 326nMAssay Description:Binding affinity to human LCK by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCyclin-G-associated kinase(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 492nMAssay Description:Binding affinity to human GAK by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 586nMAssay Description:Binding affinity to human ULK1 by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 594nMAssay Description:Binding affinity to human KIT by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 2.08E+3nMAssay Description:Binding affinity to human ULK2 by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660682BDBM50660682(CHEMBL6162015)
Affinity DataIC50: 2.66E+3nMAssay Description:Binding affinity to human MEK5 by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed