BDBM50665224 CHEMBL6145526

SMILES C[C@@H]1C[C@H](N2CCCCCN3/C(=N/S(=O)(=O)c4ccc(O)c(c4)C2=O)Sc2c(Cl)ccc(O)c23)C[C@H](C)N1Cc1ccccc1

InChI Key InChIKey=OXIBFTQXHPOBIZ-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50665224   

TargetGTPase KRas(Human)
CRUK Scotland Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665224BDBM50665224(CHEMBL6145526)
Affinity DataKd:  87nMAssay Description:Binding affinity to GDP-bound KRAS G12D mutant (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
CRUK Scotland Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665224BDBM50665224(CHEMBL6145526)
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of MANT-GDP loaded Kras G12D mutant (1 to 169 residues) (unknown origin)/SOS1 (546 to 1049 residues) (unknown origin) protein-protein inte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
CRUK Scotland Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665224BDBM50665224(CHEMBL6145526)
Affinity DataKd:  1.94E+3nMAssay Description:Binding affinity to GMPPNP-bound KRAS G12D mutant (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed