BDBM50665979 CHEMBL6175722

SMILES Nc1ncn(-c2c(Cl)cc(C(F)CF)cc2Cl)c(=O)c1C(=O)Nc1cncc([C@H]2CCCCN2)c1

InChI Key InChIKey=CUNCVWDUAGWLLO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50665979   

TargetGlycogen synthase kinase-3 alpha(Human)
Emory University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665979BDBM50665979(CHEMBL6175722)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length human GSK3alpha extracted from baculovirus expression system using 5-FAM-KRREILSRRPpSYR-COOH as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Emory University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665979BDBM50665979(CHEMBL6175722)
Affinity DataIC50: 140nMAssay Description:Inhibition of Nanoluc-GSK2beta (unknown origin) expressed in HEK293 cells measured after overnight incubation by NanoBRET- cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Emory University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665979BDBM50665979(CHEMBL6175722)
Affinity DataIC50: 163nMAssay Description:Inhibition of full length human GSK3beta extracted from baculovirus expression system using 5-FAM-KRREILSRRPpSYR-COOH as substrate preincubated for 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed