BDBM50667897 CHEMBL6192814

SMILES C#Cc1cc(NC(=O)c2ccc(-n3cnc(F)c3)nn2)c(C(=O)[O-])cc1F

InChI Key InChIKey=IMONFGQXKOLMIP-UHFFFAOYSA-M

Data  5 IC50  1 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50667897   

TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667897BDBM50667897(CHEMBL6192814)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to N-terminal 6xHis-tagged human STING R232H mutant CTD extracted from Escherichia coli BL21(DE3) assessed as dissociation constant ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667897BDBM50667897(CHEMBL6192814)
Affinity DataEC50:  60nMAssay Description:Agonist activity at STING in human THP1-Blue ISG cells harbouring SEAP reporter gene assessed as activation of cGAS-STING signaling pathway incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667897BDBM50667897(CHEMBL6192814)
Affinity DataIC50: 770nMAssay Description:Displacement of 5-FAM-labeled diABZI tracer from N-terminal 6xHis-tagged human STING R232H mutant CTD extracted from Escherichia coli BL21(DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667897BDBM50667897(CHEMBL6192814)
Affinity DataIC50: 800nMAssay Description:Displacement of 5-FAM-labeled diABZI tracer from N-terminal 6xHis-tagged human STING G230A/R293Q mutant CTD extracted from Escherichia coli BL21(DE3)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667897BDBM50667897(CHEMBL6192814)
Affinity DataIC50: 900nMAssay Description:Displacement of 5-FAM-labeled diABZI tracer from N-terminal 6xHis-tagged wild-type human STING CTD extracted from Escherichia coli BL21(DE3) incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667897BDBM50667897(CHEMBL6192814)
Affinity DataIC50: 1.15E+3nMAssay Description:Displacement of 5-FAM-labeled diABZI tracer from N-terminal 6xHis-tagged human STING R293Q mutant CTD extracted from Escherichia coli BL21(DE3) incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667897BDBM50667897(CHEMBL6192814)
Affinity DataIC50: 1.53E+3nMAssay Description:Displacement of 5-FAM-labeled diABZI tracer from N-terminal 6xHis-tagged wild-type mouse STING CTD extracted from Escherichia coli BL21(DE3) incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667897BDBM50667897(CHEMBL6192814)
Affinity DataEC50:  1.42E+4nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG cells harbouring SEAP reporter gene assessed as activation of cGAS-STING signaling pathway incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667897BDBM50667897(CHEMBL6192814)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG-KO-STING cells harbouring SEAP reporter gene assessed as activation of cGAS-STING signaling pathway ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667897BDBM50667897(CHEMBL6192814)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1-Dual KO-STING cells harbouring SEAP reporter gene assessed as activation of cGAS-STING signaling pathway incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed