BDBM50668088 CHEMBL6190950

SMILES COc1c(Nc2cc(C)[nH]n2)nc(Sc2ccc(S(C)(=O)=O)cc2F)nc1-c1cnn(C)c1

InChI Key InChIKey=FJLZJNQOPTWLOT-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50668088   

TargetSerine/threonine-protein kinase PLK4(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668088BDBM50668088(CHEMBL6190950)
Affinity DataIC50: 55nMAssay Description:Binding affinity to NanoLuc-fused PLK4 (unknown origin) transfected in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668088BDBM50668088(CHEMBL6190950)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of PLK4 in human RPE1-hTERT Cas9 Dp53 DPAC cells assessed as centriole depletion incubated for 6 days by DAPI staining based immunofluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed