BDBM507083 US11046672, Example 32

SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCN4CCN(C)CC4)c(F)c3)c3ccccc3)c2cc1C

InChI Key InChIKey=PIKYCWIZICBHRG-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 507083   

TargetPlatelet-derived growth factor receptor beta(Human)
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US Patent
LigandPNGBDBM507083(US11046672, Example 32)
Affinity DataKi:  4.92nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
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US Patent
LigandPNGBDBM507083(US11046672, Example 32)
Affinity DataKi:  10.5nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
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US Patent
LigandPNGBDBM507083(US11046672, Example 32)
Affinity DataKi:  10.7nMAssay Description:The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
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US Patent
LigandPNGBDBM507083(US11046672, Example 32)
Affinity DataKi:  19.6nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
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US Patent
LigandPNGBDBM507083(US11046672, Example 32)
Affinity DataKi:  28.7nMAssay Description:The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
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US Patent
LigandPNGBDBM507083(US11046672, Example 32)
Affinity DataKi:  106nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent