BDBM508331 1-(2-chlorophenyl)-7-cyclopropyl-4- (isothiazol-4-ylamino)quinazolin- 2(1H)-one::US11046691, Compound 642::US11084798, Cpd No 642::US11130759, Cpd. No. 642

SMILES Clc1ccccc1-n1c2cc(ccc2c(Nc2cnsc2)nc1=O)C1CC1

InChI Key InChIKey=VWXORMVPSIUAAO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 508331   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM508331(US11130759, Cpd. No. 642 | US11046691, Compound 64...)
Affinity DataIC50: 200nMAssay Description:MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM508331(US11130759, Cpd. No. 642 | US11046691, Compound 64...)
Affinity DataIC50: 200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM508331(US11130759, Cpd. No. 642 | US11046691, Compound 64...)
Affinity DataIC50: 200nMAssay Description:For the assay, a mixture of 1 mM L-methionine/1 mM ATP (2× final pre-stopped concentration) in assay buffer; MAT2A (2× final pre-stopped concentratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent