BDBM508451 2-((1-(2-chlorophenyl)-2-oxo-7- (trifluoromethyl)-1,2- dihydropyrido[2,3-4pyrimidin-4- yl)amino)-N,N- dimethylethanesulfonamide::US11046691, Compound 762::US11130759, Cpd. No. 762

SMILES CN(C)S(=O)(=O)CCNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F

InChI Key InChIKey=IMGIAMLCAKPZSD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 508451   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Bioscience

US Patent
LigandPNGBDBM508451(US11130759, Cpd. No. 762 | US11046691, Compound 76...)
Affinity DataIC50: 200nMAssay Description:For the assay, a mixture of 1 mM L-methionine/1 mM ATP (2× final pre-stopped concentration) in assay buffer; MAT2A (2× final pre-stopped concentratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Bioscience

US Patent
LigandPNGBDBM508451(US11130759, Cpd. No. 762 | US11046691, Compound 76...)
Affinity DataIC50: 200nMAssay Description:MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent