BDBM508464 (R)-1-(1-(1H-imidazol-4-yl)ethyl)-4- (methylamino)-7- (trifluoromethyl)quinazolin-2(1H)-one, single unknown enantiomer::US11046691, Compound 775::US11084798, Cpd No 775::US11130759, Cpd. No. 775

SMILES CNc1nc(=O)n([C@H](C)c2c[nH]cn2)c2cc(ccc12)C(F)(F)F

InChI Key InChIKey=LQRYQAIZKALPOC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 508464   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM508464(US11130759, Cpd. No. 775 | US11046691, Compound 77...)
Affinity DataIC50: 200nMAssay Description:MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM508464(US11130759, Cpd. No. 775 | US11046691, Compound 77...)
Affinity DataIC50: 200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM508464(US11130759, Cpd. No. 775 | US11046691, Compound 77...)
Affinity DataIC50: 200nMAssay Description:For the assay, a mixture of 1 mM L-methionine/1 mM ATP (2× final pre-stopped concentration) in assay buffer; MAT2A (2× final pre-stopped concentratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent