BDBM509516 US11072619, Example 2

SMILES COc1ccc(F)c(c1)-c1cc2ncc(C(N)=O)c(N[C@@H]3CCN(CC3(C)C)c3ccc(nn3)C#N)n2n1

InChI Key InChIKey=LYLLCQWYSUYGGS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 509516   

TargetTyrosine-protein kinase JAK1(Human)
Celon Pharma

US Patent
LigandPNGBDBM509516(US11072619, Example 2)
Affinity DataIC50: 3.74nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Celon Pharma

US Patent
LigandPNGBDBM509516(US11072619, Example 2)
Affinity DataIC50: 3.77nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Celon Pharma

US Patent
LigandPNGBDBM509516(US11072619, Example 2)
Affinity DataIC50: 59.3nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
US Patent