BDBM509517 (R)-7-((1-(6-Cyanopyridazin-3-yl)-3,3-dimethylpiperidin-4-yl)amino)-2-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carboxamide::US11072619, Example 3

SMILES CC1(C)CN(CC[C@H]1Nc1c(cnc2cc(nn12)-c1cccnc1)C(N)=O)c1ccc(nn1)C#N

InChI Key InChIKey=LWEDGUAWGGCPNU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 509517   

TargetTyrosine-protein kinase JAK3(Human)
Celon Pharma

US Patent
LigandPNGBDBM509517(US11072619, Example 3 | (R)-7-((1-(6-Cyanopyridazi...)
Affinity DataIC50: 1.58nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Celon Pharma

US Patent
LigandPNGBDBM509517(US11072619, Example 3 | (R)-7-((1-(6-Cyanopyridazi...)
Affinity DataIC50: 4.47nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Celon Pharma

US Patent
LigandPNGBDBM509517(US11072619, Example 3 | (R)-7-((1-(6-Cyanopyridazi...)
Affinity DataIC50: 31.1nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
US Patent