BDBM509518 US11072619, Example 4

SMILES COc1ccc(cn1)-c1cc2ncc(C(N)=O)c(N[C@@H]3CCN(CC3(C)C)c3ccc(nn3)C#N)n2n1

InChI Key InChIKey=QUZAOGVECIEWLE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 509518   

TargetTyrosine-protein kinase JAK1(Human)
Celon Pharma

US Patent
LigandPNGBDBM509518(US11072619, Example 4)
Affinity DataIC50: 2.67nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Celon Pharma

US Patent
LigandPNGBDBM509518(US11072619, Example 4)
Affinity DataIC50: 2.67nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Celon Pharma

US Patent
LigandPNGBDBM509518(US11072619, Example 4)
Affinity DataIC50: 27.7nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
US Patent