BDBM509520 US11072619, Example 6

SMILES CC1(C)CN(CC[C@H]1Nc1c(cnc2cc(nn12)-c1ccc(N)nc1)C(N)=O)c1ccc(nn1)C#N

InChI Key InChIKey=JXSIEYYMYPREPS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 509520   

TargetTyrosine-protein kinase JAK3(Human)
Celon Pharma

US Patent
LigandPNGBDBM509520(US11072619, Example 6)
Affinity DataIC50: 0.160nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Celon Pharma

US Patent
LigandPNGBDBM509520(US11072619, Example 6)
Affinity DataIC50: 0.380nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Celon Pharma

US Patent
LigandPNGBDBM509520(US11072619, Example 6)
Affinity DataIC50: 2.98nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
US Patent