BDBM510052 N-(2-chloro-3-(trifluoro methyl)benzyl)-8-oxo-5, 6,7,8-tetrahydroquinoline- 5-carboxamide::US11077100, Example 2::US11439633, Example 2

SMILES FC(F)(F)c1cccc(CNC(=O)C2CCC(=O)c3ncccc23)c1Cl

InChI Key InChIKey=NPABDSZTIVRCAT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 510052   

TargetP2X purinoceptor 7(Human)
Raqualia Pharma

US Patent
LigandPNGBDBM510052(N-(2-chloro-3-(trifluoro methyl)benzyl)-8-oxo-5, 6...)
Affinity DataIC50: 50nMAssay Description:1. Wash each well with 80 microL of assay buffer (20 mM HEPES, 1×HBSS, pH 7.4 adjusted with NaOH) three times and leave 20 microL using plate washer,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Raqualia Pharma

US Patent
LigandPNGBDBM510052(N-(2-chloro-3-(trifluoro methyl)benzyl)-8-oxo-5, 6...)
Affinity DataIC50: 50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Raqualia Pharma

US Patent
LigandPNGBDBM510052(N-(2-chloro-3-(trifluoro methyl)benzyl)-8-oxo-5, 6...)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM510052(N-(2-chloro-3-(trifluoro methyl)benzyl)-8-oxo-5, 6...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at rat P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Raqualia Pharma

US Patent
LigandPNGBDBM510052(N-(2-chloro-3-(trifluoro methyl)benzyl)-8-oxo-5, 6...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human P2X7 receptor transfected in HEK293 cells by calcium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM510052(N-(2-chloro-3-(trifluoro methyl)benzyl)-8-oxo-5, 6...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat P2X7 receptor transfected in HEK293 cells by calcium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed