BDBM510159 N-(2-chloro-3-(trifluoro- methyl)benzyl)-5-fluoro-8- hydroxy-5,6,7,8-tetrahydro- quinoline-5-carboxamide::US11077100, Example 19::US11439633, Example 19

SMILES OC1CCC(F)(C(=O)NCc2cccc(c2Cl)C(F)(F)F)c2cccnc12

InChI Key InChIKey=PHMYOEMHIWTAFG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 510159   

TargetP2X purinoceptor 7(Human)
Raqualia Pharma

US Patent
LigandPNGBDBM510159(N-(2-chloro-3-(trifluoro- methyl)benzyl)-5-fluoro-...)
Affinity DataIC50: 50nMAssay Description:1. Wash each well with 80 microL of assay buffer (20 mM HEPES, 1×HBSS, pH 7.4 adjusted with NaOH) three times and leave 20 microL using plate washer,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Raqualia Pharma

US Patent
LigandPNGBDBM510159(N-(2-chloro-3-(trifluoro- methyl)benzyl)-5-fluoro-...)
Affinity DataIC50: 50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Raqualia Pharma

US Patent
LigandPNGBDBM510159(N-(2-chloro-3-(trifluoro- methyl)benzyl)-5-fluoro-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human P2X7 receptor transfected in HEK293 cells by calcium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM510159(N-(2-chloro-3-(trifluoro- methyl)benzyl)-5-fluoro-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat P2X7 receptor transfected in HEK293 cells by calcium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed