BDBM510496 US11077111, Compound IVa::US20230295171, Example 29

SMILES Cn1cc(cn1)-c1nc(N[C@@H]2CCCC[C@@H]2N)c(Cl)c2CNC(=O)c12

InChI Key InChIKey=IYJQOJUTDKHGSO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 510496   

TargetInterleukin 1 receptor associated kinase 4(Dog)
Bayer Animal Health

US Patent
LigandPNGBDBM510496(US11077111, Compound IVa | US20230295171, Example ...)
Affinity DataIC50: 10.2nMAssay Description:A radiometric protein kinase assay was used for measuring the kinase activity of the Dog (Canis lupus familiaris) IRAK4, JAK1, JAK2, SYK kinases. All...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
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TargetTyrosine-protein kinase(Dog)
Bayer Animal Health

US Patent
LigandPNGBDBM510496(US11077111, Compound IVa | US20230295171, Example ...)
Affinity DataIC50: 466nMAssay Description:A radiometric protein kinase assay was used for measuring the kinase activity of the Dog (Canis lupus familiaris) IRAK4, JAK1, JAK2, SYK kinases. All...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase(Dog)
Bayer Animal Health

US Patent
LigandPNGBDBM510496(US11077111, Compound IVa | US20230295171, Example ...)
Affinity DataIC50: 624nMAssay Description:A radiometric protein kinase assay was used for measuring the kinase activity of the Dog (Canis lupus familiaris) IRAK4, JAK1, JAK2, SYK kinases. All...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase(Red fox)
Bayer Animal Health

US Patent
LigandPNGBDBM510496(US11077111, Compound IVa | US20230295171, Example ...)
Affinity DataIC50: 323nMAssay Description:A radiometric protein kinase assay was used for measuring the kinase activity of the Dog (Canis lupus familiaris) IRAK4, JAK1, JAK2, SYK kinases. All...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM510496(US11077111, Compound IVa | US20230295171, Example ...)
Affinity DataIC50: 3.16nMAssay Description:YK protein is prepared from cDNA encoding human spleen tyrosine kinase and is expressed in insect cells using a baculovirus expression vector. The cD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
Go to US Patent