BDBM510844 4-({(aR)-6-[6-(2- hydroxy-2- methylpropoxy)pyrazolo [1,5-a]pyridine-3- amido]spiro[3.3] heptan-2-yl}oxy)-2- methyl-1,3-thiazole- 5-carboxamide::US11078197, Example 21::US11673886, Example 21

SMILES Cc1nc(O[C@H]2C[C@@]3(C[C@@H](C3)NC(=O)c3cnn4cc(OCC(C)(C)O)ccc34)C2)c(s1)C(N)=O

InChI Key InChIKey=BTHYXNGSLJJRCR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510844   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510844(4-({(aR)-6-[6-(2- hydroxy-2- methylpropoxy)pyrazol...)
Affinity DataIC50: 18.9nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510844(4-({(aR)-6-[6-(2- hydroxy-2- methylpropoxy)pyrazol...)
Affinity DataIC50: 1.89E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent