BDBM510887 2-cyclopropyl-4- {[(aR)-6-[3- (trifluoromethyl) imidazo[1,5-a]pyridine- 1-amido]spiro[3.3] heptan-2-yl]oxy}-1,3- thiazole-5- carboxamide::US11078197, Example 64::US11673886, Example 64

SMILES NC(=O)c1sc(nc1O[C@H]1C[C@@]2(C[C@@H](C2)NC(=O)c2nc(n3ccccc23)C(F)(F)F)C1)C1CC1

InChI Key InChIKey=CGVLADHYUZHVQO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510887   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510887(2-cyclopropyl-4- {[(aR)-6-[3- (trifluoromethyl) im...)
Affinity DataIC50: 11.4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510887(2-cyclopropyl-4- {[(aR)-6-[3- (trifluoromethyl) im...)
Affinity DataIC50: 1.14E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent